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Heme oxygenase modulates selectin expression in different regional vascular beds

Br J Clin Pharmacol 2025 demonstrates that co-infusing a GLP-1 agonist with glucagon produces a perfectly additive HR response (+4 bpm + +4 bpm = +7 bpm at 60 min in n=12 lean males), confirming that glucagon drives chronotropy via a parallel pathway independent of GLP-1R cross-reactivity

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subtilis mutant RK6121 resistant to 8-azaguanine, methionine sulfoxide, diacetyl, and psicofuranine which contained, in addition, a plasmid with the mutated rib operon (Table 1)